pI: 6.816 |
Length (AA): 156 |
MW (Da): 17818 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129756)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_36185 | Hypothetical 23.7 kDa protein in CYR1-OST1 intergenic region |
Candida albicans | CaO19_7128 | hypothetical protein |
Candida albicans | CaO19.7128 | similar to mammalian SPC12 |
Caenorhabditis elegans | CELE_T03F1.12 | Protein T03F1.12 |
Dictyostelium discoideum | DDB_G0269368 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11753 | CG11753 gene product from transcript CG11753-RC |
Echinococcus granulosus | EgrG_000464000 | protein sys1 |
Echinococcus multilocularis | EmuJ_000464000 | protein sys1 |
Homo sapiens | ENSG00000204070 | Sys1 golgi trafficking protein |
Loa Loa (eye worm) | LOAG_02701 | hypothetical protein |
Mus musculus | ENSMUSG00000045503 | SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) |
Neospora caninum | NCLIV_047210 | hypothetical protein, conserved |
Oryza sativa | 4326384 | Os01g0593600 |
Onchocerca volvulus | OVOC539 |
|
Plasmodium falciparum | PF3D7_0621350 | protein SYS1, putative |
Saccharomyces cerevisiae | YJL004C | Sys1p |
Schistosoma japonicum | Sjp_0014570 | Protein SYS1 homolog, putative |
Schistosoma mansoni | Smp_038410 | hypothetical protein |
Schmidtea mediterranea | mk4.000994.00 | Protein SYS1 homolog |
Toxoplasma gondii | TGME49_225500 | hypothetical protein |
Trichomonas vaginalis | TVAG_266030 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_225500 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.